DICON physicians Drs. Jessica Seidelman, Becky Smith, Christopher Shoff, Art Baker, Sarah Lewis, Deverick Anderson, and Dan Sexton performed a retrospective analysis of prospectively collected data on 7 categories of surgical procedures performed over a 4-year period (July 2013–December 2017) at 3 Duke University Health System (DUHS)–affiliated hospitals. This cohort included adult patients who underwent craniotomy, spinal fusion, laminectomy, hip arthroplasty, knee arthroplasty, and cardiac bypass surgeries. Trained infection preventionists reviewed the cases for SSI using current NHSN definitions. Surveillance for SSIs was primarily culture-based in all 3 hospitals.